Knowledge Papers

POWER AND RETURN ON INVESTMENT

“At some point, perhaps not in the far future, it will seem as wrong to run a clinical trial without compliance measurement as without randomization.” B. Efron, Statistics in Medicine, 1998 (17), 249-250.
Of course we are all aware of the central role played by randomization in the clinical research process. Virtually all clinical research employs this technique. However clinicians are generally surprised to hear that the physical sciences get along quite nicely without randomization.